Error 330 net::ERR_CONTENT_DECODING_FAILED with Minify on first load
This seems to be a bug in 2.1.5. I had the same problem you described, but only in 2.1.5 so I downgraded to 2.1.3 and it works.
Here is the download link to 2.1.3:
http://code.google.com/p/minify/downloads/detail?name=minify_2.1.3.zip
PHP | Getting ERR_CONTENT_DECODING_FAILED in Ajax request
In my experience this error comes up when there is a php error and compression is turned on. Go to Admin > System > Settings and then to the Server tab and set Output Compression Level to 0. Also make sure Display Errors is set to ON.
Now inspect the response from your Ajax call and instead of a decoding error you will be able to see the actual error that's being reported.
Also remember if it's a FATAL error the script can crash before it even gets a chance to initialize the custom error handler and the the only way to get data about these will be in the webserver error logs.
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